Nanoparticles improved resveratrol brain delivery and its therapeutic efficacy against intracerebral hemorrhage

Author:

Mo Yousheng1234ORCID,Duan Lining5234,Yang Yuna6234,Liu Wei1234,Zhang Ying1234,Zhou Ligui6234,Su Shiyu5234,Lo Po-Chieh1234,Cai Jiaying1234,Gao Liqian7894ORCID,Liu Qiao101112134,Chen Xiaojia101112134,Yang Cong1234,Wang Qi1234,Chen Tongkai1234ORCID

Affiliation:

1. Science and Technology Innovation Center

2. Guangzhou University of Chinese Medicine

3. Guangzhou 510405

4. China

5. Clinical Medical College of Acupuncture Moxibustion and Rehabilitation

6. Laboratory Animal Center

7. School of Pharmaceutical Sciences (Shenzhen)

8. Sun Yat-sen University

9. Shenzhen 518107

10. State Key Laboratory of Quality Research in Chinese Medicine

11. Institute of Chinese Medical Sciences

12. University of Macau

13. Macau 999078

Abstract

Polymer nanoparticles (NPs) increase resveratrol (Res) oral bioavailability in intracerebral hemorrhage (ICH) and the anti-ferroptosis mechanism of Res-NPs.

Funder

Guangzhou Science, Technology and Innovation Commission

Natural Science Foundation of Guangdong Province

Universidade de Macau

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

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