Design, synthesis, anti-proliferative evaluation and docking studies of 1H-1,2,3-triazole tethered ospemifene–isatin conjugates as selective estrogen receptor modulators-Reference-Cited by-同舟云学术

Design, synthesis, anti-proliferative evaluation and docking studies of 1H-1,2,3-triazole tethered ospemifene–isatin conjugates as selective estrogen receptor modulators

Published:2018 Issue:5 Volume:42 Page:3703-3713
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

Kumar Sumit¹²³⁴,Gu Liang⁵⁶⁷⁸⁹,Palma Gabriella⁵⁶⁷⁸⁹,Kaur Mandeep⁵⁶⁷⁸⁹,Singh-Pillay Ashona¹⁰¹¹¹²¹³¹⁴,Singh Parvesh¹⁰¹¹¹²¹³¹⁴,Kumar Vipan¹²³⁴^ORCID

Affiliation:

1. Department of Chemistry

2. Guru Nanak Dev University

3. Amritsar-143005

4. India

5. School of Molecular and Cell Biology

6. University of the Witwatersrand

7. Private Bag 3

8. Johannesburg

9. South Africa

10. School of Chemistry and Physics

11. University of KwaZulu Natal

12. P/Bag X54001

13. Westville

14. Durban 4000

Abstract

A library of 1H-1,2,3-triazole-tethered ospemifene–isatin and ospemifene–spiroisatin conjugates have been synthesized and evaluated for their anti-proliferative activities against MCF-7 and MDA-MB-231 cell lines.

Funder

National Research Foundation

University of the Witwatersrand, Johannesburg

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2018/NJ/C7NJ04964A

Reference35 articles.

1. Synthesis and Biological Evaluation of Selective Aromatase Expression Regulators in Breast Cancer Cells

2. American Cancer Society. Cancer facts and figures 2017. https://www.cancer.org/research/cancer-facts-statistics/all-cancer-facts-figures/cancer-facts-figures-2017.html

3. Long-term effects of continuing adjuvant tamoxifen to 10 years versus stopping at 5 years after diagnosis of oestrogen receptor-positive breast cancer: ATLAS, a randomised trial

Cited by 24 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Synthesis of potent MDA-MB 231 breast cancer drug molecules from single step;Scientific Reports;2023-10-25

2. A Mini Review on Pharmacological Significance of Isatin-1,2,3-Triazole Hybrids;Current Topics in Medicinal Chemistry;2023-04

3. Therapeutic significance of molecular hybrids for breast cancer research and treatment;RSC Medicinal Chemistry;2023

4. A single-pot synthesis of 4-hydroxybenzophenones via acid-catalyzed alkoxylation of p-quinone methides followed by DDQ-assisted oxo-demethoxylation;New Journal of Chemistry;2023

5. Selective Estrogen Receptor Modulators (SERMs) for the treatment of ER+ breast cancer: An overview;Journal of Molecular Structure;2022-12