Cochlear implant-based electric-acoustic stimulation modulates neural stem cell-derived neural regeneration

Author:

Guo Rongrong123,Liao Menghui34,Ma Xiaofeng567,Hu Yangnan34,Qian Xiaoyun67,Xiao Miao1ORCID,Gao Xia67,Chai Renjie34,Tang Mingliang134ORCID

Affiliation:

1. Institute for Cardiovascular Science & Department of Cardiovascular Surgery of the First Affiliated Hospital, Medical College, Soochow University, Suzhou, 215000, China

2. State Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, Yunnan, 650500, China

3. Key Laboratory for Developmental Genes and Human Disease, Ministry of Education, School of Life Science and Technology, Southeast University, Nanjing 210096, China

4. Co-innovation Center of Neuroregeneration, Nantong University, Nantong 226001, China

5. Department of Otorhinolaryngology-Head and Neck Surgery, Nanjing Drum Tower Hospital, Clinical College of Nanjing Medical University, Nanjing, Jiangsu 210008, China

6. Department of Otorhinolaryngology-Head and Neck Surgery, Affiliated Drum Tower Hospital of Nanjing University Medical School, Jiangsu Provincial Key Medical Discipline (Laboratory), Nanjing, Jiangsu 210008, China

7. Research Institution of Otorhinolaryngology, Nanjing, Jiangsu 210008, P. R. China

Abstract

A cochlear implant based device was designed to stimulate NSCs. It is found that electric-acoustic stimulation with high frequency induced NSCs death but low-frequency stimulation promoted NSCs to proliferate and differentiate into neurons.

Funder

Major State Basic Research Development Program of China

National Natural Science Foundation of China

Natural Science Foundation of Jiangsu Province

Fundamental Research Funds for the Central Universities

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

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