Discovery, affinity maturation and multimerization of small molecule ligands against human tyrosinase and tyrosinase-related protein 1-Reference-Cited by-同舟云学术

Discovery, affinity maturation and multimerization of small molecule ligands against human tyrosinase and tyrosinase-related protein 1

Published:2021 Issue:3 Volume:12 Page:363-369
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Catalano Marco¹²³⁴^ORCID,Bassi Gabriele¹²³⁴,Rotondi Giulia¹²³⁴⁵,Khettabi Lyna⁶⁷⁸⁹¹⁰,Dichiara Maria¹²³⁴,Murer Patrizia¹²³⁴,Scheuermann Jörg¹²³⁴,Soler-Lopez Montserrat⁶⁷⁸⁹,Neri Dario¹²³⁴

Affiliation:

1. Department of Chemistry and Applied Biosciences

2. Swiss Federal Institute of Technology (ETH Zürich)

3. CH-8093 Zürich

4. Switzerland

5. Dipartimento di Chimica e Tecnologie del Farmaco

6. Structural Biology Group

7. European Synchrotron Radiation Facility

8. 38000 Grenoble

9. France

10. CNRS

Abstract

A series of different strategies were oriented toward the discovery of small molecule ligands binding to the human version of tyrosinase (hTYR) and tyrosinase-related protein 1 (hTYRP1), which may represent the basis for novel treatments of melanoma.

Funder

Université Grenoble Alpes

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

H2020 European Research Council

ETH Zürich Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/MD/D0MD00310G

Reference70 articles.