A practical base mediated synthesis of 1,2,4-triazoles enabled by a deamination annulation strategy-Reference-Cited by-同舟云学术

A practical base mediated synthesis of 1,2,4-triazoles enabled by a deamination annulation strategy

Published:2020 Issue:91 Volume:56 Page:14215-14218
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Zhang Chunyan¹²³⁴⁵^ORCID,Liang Zuyu¹²³⁴⁵,Jia Xiaofei¹²³⁴⁵^ORCID,Wang Maorong⁶⁷⁸⁹,Zhang Guoying¹²³⁴⁵^ORCID,Hu Mao-Lin¹⁰¹¹¹²⁹^ORCID

Affiliation:

1. Key Laboratory of Sensor Analysis of Tumor Marker

2. Ministry of Education

3. Shan-dong Key Laboratory of Biochemical Analysis

4. Key Laboratory of Analytical Chem-istry for Life Science in Universities of Shandong

5. Key Laboratory of Optic-electric Sensing and Analytical Chemistry for Life Science

6. State Key Laboratory of Bio-Fibers and Eco-Textiles

7. Qingdao University

8. Qingdao

9. P. R. China

10. College of Chemistry and Materials Engineering

11. Wenzhou University

12. Wenzhou 325035

Abstract

t-BuOK mediates the deamination annulation of nitriles with hydrazines for the synthesis of 1,2,4-triazoles. This protocol provides a practical strategy to construct ¹⁵N-labeled 1,2,4-triazoles and protein antagonists and the receptor mGlu5 in one-pot.

Funder

Natural Science Foundation of Shandong Province

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2020/CC/D0CC05828A

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