MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling

Author:

Burnum-Johnson Kristin E.1234ORCID,Kyle Jennifer E.1234,Eisfeld Amie J.56789,Casey Cameron P.1234,Stratton Kelly G.1234,Gonzalez Juan F.1011124,Habyarimana Fabien1011124,Negretti Nicholas M.131415164,Sims Amy C.1718194,Chauhan Sadhana2021224,Thackray Larissa B.2324252627,Halfmann Peter J.56789,Walters Kevin B.56789,Kim Young-Mo1234,Zink Erika M.1234,Nicora Carrie D.1234,Weitz Karl K.1234,Webb-Robertson Bobbie-Jo M.28234,Nakayasu Ernesto S.1234,Ahmer Brian1011124,Konkel Michael E.131415164,Motin Vladimir2021224,Baric Ralph S.1718194,Diamond Michael S.2324252627,Kawaoka Yoshihiro56789,Waters Katrina M.1234,Smith Richard D.1234,Metz Thomas O.1234ORCID

Affiliation:

1. Biological Sciences Division

2. Pacific Northwest National Laboratory

3. Richland

4. USA

5. Influenza Research Institute

6. Department of Pathobiological Sciences

7. School of Veterinary Medicine

8. University of Wisconsin-Madison

9. Madison

10. Department of Microbial Infection and Immunity

11. Ohio State University

12. Columbus

13. School of Molecular Biosciences

14. College of Veterinary Medicine

15. Washington State University

16. Pullman

17. Department of Epidemiology

18. University of North Carolina at Chapel Hill

19. Chapel Hill

20. Department of Pathology

21. University of Texas Medical Branch

22. Galveston

23. Departments of Medicine

24. Molecular Microbiology

25. Pathology & Immunology

26. Washington University School of Medicine

27. St. Louis

28. Computational and Statistical Analytics Division

Abstract

The continued emergence and spread of infectious agents is of great concern, and systems biology approaches to infectious disease research can advance our understanding of host–pathogen relationships and facilitate the development of new therapies and vaccines.

Funder

National Institute of Allergy and Infectious Diseases

National Institute of General Medical Sciences

Publisher

Royal Society of Chemistry (RSC)

Subject

Electrochemistry,Spectroscopy,Environmental Chemistry,Biochemistry,Analytical Chemistry

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