Synthesis and evaluation of 3′-[18F]fluorothymidine-5′-squaryl as a bioisostere of 3′-[18F]fluorothymidine-5′-monophosphate
Author:
Affiliation:
1. Comprehensive Cancer Imaging Centre
2. Faculty of Medicine
3. Imperial College London
4. Hammersmith Hospital
5. UK
6. University of Kentucky
7. Department of Chemistry
8. Lexington
9. USA
Abstract
[18F]SqFLT was developed to bypass thymidine kinase 1 (TK1) and evaluated for PET imaging of DNA synthesis.
Funder
Cancer Research UK
Medical Research Council
NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research
Publisher
Royal Society of Chemistry (RSC)
Subject
General Chemical Engineering,General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2021/RA/D1RA00205H
Reference35 articles.
1. The Influence of Bioisosteres in Drug Design: Tactical Applications to Address Developability Problems
2. Structure Property Relationships of Carboxylic Acid Isosteres
3. Squaramide‐Based 5’‐Phosphate Replacements Bind to the DNA Repair Exonuclease SNM1A
4. Squaryl Group as a New Mimic of Phosphate Group in Modified Oligodeoxynucleotides: Synthesis and Properties of New Oligodeoxynucleotide Analogues Containing an Internucleotidic Squaryldiamide Linkage
5. Synthesis and Properties of New Nucleotide Analogues Possessing Squaramide Moieties as New Phosphate Isosters
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