A sialosyl sulfonate as a potent inhibitor of influenza virus replication
Author:
Affiliation:
1. Institute for Glycomics
2. Griffith University – Gold Coast Campus
3. Queensland 4222
4. Australia
5. Department of Pharmaceutical Chemistry
6. University of Debrecen
7. H-4032 Debrecen
8. Hungary
Abstract
A 2-deoxy-sialosyl sulfonate, synthesised in just four steps from sialic acid, is >500-fold more potent against influenza virus sialidase activity and cell infection than its carboxylate isostere.
Funder
National Health and Medical Research Council
Publisher
Royal Society of Chemistry (RSC)
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2017/OB/C7OB00947J
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