Synthesis and evaluation of influenza A viral neuraminidase candidate inhibitors based on a bicyclo[3.1.0]hexane scaffold
Author:
Affiliation:
1. Department of Chemistry
2. Simon Fraser University
3. 8888 University Drive
4. British Columbia
5. Canada V5A 1S6
6. Università degli Studi di Milano
7. Dipartimento di Chimica
8. I-20133 Milano
9. Italy
Abstract
We describe the synthesis of constrained oseltamivir analogues designed to mimic the proposed boat conformation of the enzymatic transition state.
Funder
Seventh Framework Programme
Canadian Institutes of Health Research
Publisher
Royal Society of Chemistry (RSC)
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2016/OB/C6OB00999A
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