Subtle sequence variations alter tripartite complex kinetics and G-quadruplex dynamics in RNA aptamer Broccoli-Reference-Cited by-同舟云学术

Subtle sequence variations alter tripartite complex kinetics and G-quadruplex dynamics in RNA aptamer Broccoli

Published:2020 Issue:17 Volume:56 Page:2634-2637
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Savage Jonathan C.¹²³⁴,Davare Monika A.⁵⁶⁷⁸³,Shinde Ujwal¹²³⁴^ORCID

Affiliation:

1. Department of Chemical Physiology & Biochemistry

2. Oregon Health & Science University

3. Portland

4. USA

5. Papé Pediatric Research Institute

6. Division of Pediatric Hematology/Oncology

7. Department of Pediatrics

8. Oregon Health & Sciences University

Abstract

Spectroscopic and kinetic investigations of tripartite complex formation reveal differences between Broccoli and Spinach aptamers, highlighting how subtle sequence variations impart functional consequences of G-Quadruplex–cation interactions in RNA.

Funder

National Institutes of Health

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2020/CC/C9CC09375C

Reference34 articles.

1. Systematic Evolution of Ligands by Exponential Enrichment: RNA Ligands to Bacteriophage T4 DNA Polymerase

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