A Broccoli aptamer chimera yields a fluorescent K+ sensor spanning physiological concentrations-Reference-Cited by-同舟云学术

A Broccoli aptamer chimera yields a fluorescent K+ sensor spanning physiological concentrations

Published:2021 Issue:11 Volume:57 Page:1344-1347
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Savage Jonathan C.¹²³⁴,Shinde Pushkar⁵⁶⁷⁴,Yao Yizhou¹²³⁴,Davare Monika A.⁸⁹¹⁰²³,Shinde Ujwal¹²³⁴^ORCID

Affiliation:

1. Department of Chemical Physiology & Biochemistry

2. Oregon Health & Science University

3. Portland

4. USA

5. Department of Chemistry

6. Emory University

7. Atlanta

8. Papé Family Pediatric Research Institute

9. Division of Pediatric Hematology/Oncology

10. Department of Pediatrics

Abstract

We engineered a fluorescent mixed chemistry RNA chimera using 2′fluorinated pyrimidine analogues that detect K⁺ spanning 0.1–100 mM.

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2021/CC/D0CC07042D

Reference40 articles.

1. Broccoli: Rapid Selection of an RNA Mimic of Green Fluorescent Protein by Fluorescence-Based Selection and Directed Evolution

2. RNA Mimics of Green Fluorescent Protein

3. Structural basis for activity of highly efficient RNA mimics of green fluorescent protein

4. A G-quadruplex–containing RNA activates fluorescence in a GFP-like fluorophore

5. Subtle sequence variations alter tripartite complex kinetics and G-quadruplex dynamics in RNA aptamer Broccoli

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