Dearomative intermolecular [2 + 2] photocycloaddition for construction of C(sp3)-rich heterospirocycles on-DNA

Author:

Li Longbo1ORCID,Matsuo Bianca1ORCID,Levitre Guillaume1,McClain Edward J.23,Voight Eric A.2ORCID,Crane Erika A.4,Molander Gary A.1ORCID

Affiliation:

1. Department of Chemistry, Roy and Diana Vagelos Laboratories, University of Pennsylvania, 231 South 34th Street, Philadelphia, Pennsylvania 19104-6323, USA

2. Drug Discovery Science & Technology, Discovery Research & Development, AbbVie, Inc., 1 North Waukegan Rd, North Chicago, Illinois 60064-1802, USA

3. Department of Chemistry, University of Wisconsin−Madison, Madison, Wisconsin 53706, USA

4. Drug Hunter, Inc., 13203 SE 172nd Ave, Suite 166 PMB 2019, Happy Valley, Oregon, 97086, USA

Abstract

Diverse DNA-encoded libraries of complex and novel sp3-rich spirocycles were achieved using a versatile and operationally simple visible light-mediated intermolecular [2 + 2] cycloaddition.

Funder

AbbVie

National Institute of General Medical Sciences

National Institutes of Health

National Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

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