Highly enantioselective addition of dimethylzinc to fluorinated alkyl ketones, and the mechanism behind it-Reference-Cited by-同舟云学术

Highly enantioselective addition of dimethylzinc to fluorinated alkyl ketones, and the mechanism behind it

Published:2018 Issue:83 Volume:54 Page:11809-11812
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Neves-Garcia Tomaz¹²³⁴⁵,Vélez Andrea¹²³⁴⁵^ORCID,Martínez-Ilarduya Jesús M.¹²³⁴⁵^ORCID,Espinet Pablo¹²³⁴⁵^ORCID

Affiliation:

1. IU CINQUIMA/Química Inorgánica

2. Facultad de Ciencias

3. Universidad de Valladolid

4. 47071-Valladolid

5. Spain

Abstract

Switching the solvent from toluene to dichloromethane results in a very important enhancement in the yield and enantiomeric excess of nucleophilic addition.

Funder

Banco Santander

Ministerio de Economía y Competitividad

Consejería de Educación, Junta de Castilla y León

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2018/CC/C8CC06358C

Reference40 articles.

1. Enantioselective Addition of Organometallic Reagents to Carbonyl Compounds: Chirality Transfer, Multiplication, and Amplification

2. Enantioselective addition of organozinc reagents to aldehydes

3. Organozinc mediated reactions

4. Catalytic Asymmetric Organozinc Additions to Carbonyl Compounds

5. Enantioselective addition of organozinc reagents to carbonyl compounds

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