Accessing human selenoproteins through chemical protein synthesis-Reference-Cited by-同舟云学术

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Accessing human selenoproteins through chemical protein synthesis

Published:2017 Issue:3 Volume:8 Page:1922-1926
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Dery L.¹²³⁴,Reddy P. Sai¹²³⁴,Dery S.¹²³⁴,Mousa R.¹²³⁴,Ktorza O.¹²³⁴,Talhami A.¹²³⁴,Metanis N.¹²³⁴

Affiliation:

1. Institute of Chemistry

2. The Hebrew University of Jerusalem

3. Jerusalem 91904

4. Israel

Abstract

The human body contains 25 selenoproteins, but challenges in their preparations have prevented biological characterizations thus far. Here we report the first total chemical syntheses of two human selenoproteins, selenoprotein M (SELM) and selenoprotein W (SELW).

Funder

Israel Science Foundation

German-Israeli Foundation for Scientific Research and Development

Council for Higher Education

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/SC/C6SC04123J

Reference74 articles.

1. Selenium and Selenoproteins in Health and Disease

2. Selenocysteine: the 21st amino acid

3. SELENOCYSTEINE

4. The labour pains of biochemical selenology: The history of selenoprotein biosynthesis

5. Characterization of Mammalian Selenoproteomes

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