Polyornithine-based polyplexes to boost effective gene silencing in CNS disorders-Reference-Cited by-同舟云学术

Polyornithine-based polyplexes to boost effective gene silencing in CNS disorders

Published:2020 Issue:11 Volume:12 Page:6285-6299
ISSN:2040-3364
Container-title:Nanoscale
language:en
Short-container-title:Nanoscale

Author:

Conejos-Sánchez I.¹²³⁴⁵^ORCID,Gallon E.¹²³,Niño-Pariente A.¹²³^ORCID,Smith J. A.⁴⁵⁶⁷⁸,De la Fuente A. G.⁴⁵⁶⁷⁹^ORCID,Di Canio L.⁴⁵⁶⁷⁹,Pluchino S.⁴⁵⁶⁷^ORCID,Franklin R. J. M.⁴⁵⁶⁷⁹,Vicent M. J.¹²³^ORCID

Affiliation:

1. Centro de Investigación Príncipe Felipe. Polymer Therapeutics Laboratory

2. 46012 Valencia

3. Spain

4. Dept. Clinical Neurosciences and NIHR Biomedical Research Centre

5. Clifford Allbutt Building-Cambridge Biosciences Campus

6. University of Cambridge

7. UK

8. Cambridge Innovation Technologies Consulting (CITC) Limited

9. Wellcome-Medical Research Council Cambridge Stem Cell Institute

Abstract

Novel biodegradable and biocompatible polyornithine derivatives as non-viral vectors for siRNA exhibit effectively silence gene expression in primary neural cells.

Funder

Ministerio de Ciencia e Innovación

Generalitat Valenciana

European Regional Development Fund

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

Link

http://pubs.rsc.org/en/content/articlepdf/2020/NR/C9NR06187H

Reference91 articles.

1. Current preclinical small interfering RNA (siRNA)-based conjugate systems for RNA therapeutics