Allosteric inhibition induces an open WPD-loop: a new avenue towards glioblastoma therapy
Author:
Affiliation:
1. Molecular Bio-computation and Drug Design Laboratory
2. School of Health Sciences
3. University of KwaZulu-Natal
4. Durban 4001
5. South Africa
Abstract
Structural mechanism of inhibition of NAZ2329 at the allosteric site of PTPRZ, with particular emphasis on the dynamics of the WPD-loop.
Funder
Inyuvesi Yakwazulu-Natali
Publisher
Royal Society of Chemistry (RSC)
Subject
General Chemical Engineering,General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2018/RA/C8RA08427K
Reference41 articles.
1. The Direction of Tumour Growth in Glioblastoma Patients
2. Targeting cellular pathways in glioblastoma multiforme
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4. Advances in Brain Tumor Surgery for Glioblastoma in Adults
5. Ror2 signaling regulates Golgi structure and transport through IFT20 for tumor invasiveness
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