Inhalable mucin-permeable nanomicelles deliver antibiotics for effective treatment of chronic pneumonia

Author:

Jiang Zitong1ORCID,Huo Shaohu1ORCID,Qiao Lei2,Lin Paiyu1,Fu Ling1,Wu Yaling3,Li Wenhong1,Bian Chenrong1,Li Yaoyao4,Li Nan4,Cheng Haiyan4,Nie Xuan5,Ding Shenggang16

Affiliation:

1. Department of Paediatrics, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, China

2. Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei 230026, China

3. Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, 230032, China

4. Clinical Laboratory, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, China

5. Department of Pharmacy, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Anhui Provincial Key Laboratory of Precision Pharmaceutical Preparations and Clinical Pharmacy, Hefei, Anhui, 230026, China

6. Beijing Children's Hospital, Capital Medical University, China National Clinical Research Center of Respiratory Diseases, Beijing, 100045, China

Abstract

Polymer materials with charge conversion properties can self-assemble into inhalable nano micelles and exhibit a positive charge in the acidic environment of a bacterial infection, enhancing the interaction between the antibiotic and the bacterium.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

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