A natural compound hyperoside targets <i>Salmonella</i> Typhimurium T3SS needle protein InvG-Reference-Cited by-同舟云学术

A natural compound hyperoside targets Salmonella Typhimurium T3SS needle protein InvG

Published:2022 Issue:19 Volume:13 Page:9761-9771
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Zhang Yong¹²,Liu Yan²,Zhang Bo³,Gao Longnv⁴,Jie Jing¹,Deng Xuming¹²,Liu Xiaoyun⁵^ORCID,Sun Dong⁶,Song Lei¹^ORCID,Luo Jingjing¹

Affiliation:

1. Department of Respiratory Medicine, Center for Pathogen Biology and Infectious Diseases, Key Laboratory of Organ Regeneration and Transplantation of the Ministry of Education, The First Hospital of Jilin University, Changchun 130021, China

2. Key Laboratory of Zoonosis, Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, Changchun 130062, China

3. Department of Geriatrics, The Affiliated Hospital to Changchun University of Chinese Medicine, Changchun 130062, China

4. Department of Anaesthesia, Jilin Province People's Hospital, Changchun 130062, China

5. Department of Microbiology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China

6. Department of General Surgery, Qilu Hospital of Shandong University, Jinan 250012, Shandong, P.R. China

Abstract

After entry into the host cells, Salmonella Typhimurium creates a replication niche using its Type III system (T3SS). Hyperoside targets InvG to inhibit T3SS translocation of S. Typhimurium, thus inhibiting its replication in host cells.

Funder

National Natural Science Foundation of China

First Hospital of Jilin University

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

Link

http://pubs.rsc.org/en/content/articlepdf/2022/FO/D2FO00908K

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