Organocatalytic asymmetric azidation of sulfoxonium ylides: mild synthesis of enantioenriched α-azido ketones bearing a labile tertiary stereocenter-Reference-Cited by-同舟云学术

Organocatalytic asymmetric azidation of sulfoxonium ylides: mild synthesis of enantioenriched α-azido ketones bearing a labile tertiary stereocenter

Published:2022 Issue:39 Volume:13 Page:11648-11655
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Guo Wengang¹^ORCID,Jiang Feng¹,Li Shijia²³,Sun Jianwei¹²³^ORCID

Affiliation:

1. Jiangsu Key Laboratory of Advanced Catalytic Materials & Technology, School of Petrochemical Engineering, Changzhou University, Changzhou, China

2. Department of Chemistry and the Hong Kong Branch of Chinese National Engineering Research Centre for Tissue Restoration & Reconstruction, The Hong Kong University of Science and Technology (HKUST), Clear Water Bay, Kowloon, Hong Kong SAR, China

3. Shenzhen Research Institute, HKUST, No. 9 Yuexing 1st Rd, Shenzhen 518057, China

Abstract

An organocatalytic asymmetric H–N3 insertion of α-carbonyl sulfoxonium ylides has been developed, providing efficient access to α-azido ketones bearing labile tertiary stereocenters and complementing the metal carbene insertion chemistry.

Funder

National Natural Science Foundation of China

Research Grants Council, University Grants Committee

Changzhou University

Innovation and Technology Commission

Jiangsu Key Laboratory of Advanced Catalytic Materials and Technology Department

Shenzhen Science and Technology Innovation Program

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

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