Inhibition of carbonic anhydrases by a substrate analog: benzyl carbamate directly coordinates the catalytic zinc ion mimicking bicarbonate binding-Reference-Cited by-同舟云学术

Inhibition of carbonic anhydrases by a substrate analog: benzyl carbamate directly coordinates the catalytic zinc ion mimicking bicarbonate binding

Published:2018 Issue:73 Volume:54 Page:10312-10315
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

De Simone Giuseppina¹²³^ORCID,Angeli Andrea⁴⁵⁶⁷⁸^ORCID,Bozdag Murat⁴⁵⁶⁷⁸^ORCID,Supuran Claudiu T.⁴⁵⁶⁷⁸^ORCID,Winum Jean-Yves⁹¹⁰¹¹¹²¹³^ORCID,Monti Simona Maria¹²³^ORCID,Alterio Vincenzo¹²³^ORCID

Affiliation:

1. Istituto di Biostrutture e Bioimmagini-CNR

2. Naples

3. Italy

4. Neurofarba Department

5. Section of Pharmaceutical and Nutriceutical Sciences

6. Università degli Studi di Firenze

7. Sesto Fiorentino

8. Florence

9. Institut des Biomolécules Max Mousseron (IBMM) UMR 5247 CNRS

10. ENSCM

11. Université de Montpellier

12. 240 avenue du professeur Emile Jeanbrau

13. 34296 Montpellier Cedex

Abstract

N-Unsubstituted carbamates can be used as lead compounds for the development of carbonic anhydrase inhibitors possessing a binding mode similar to bicarbonate.

Funder

Consiglio Nazionale delle Ricerche

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2018/CC/C8CC05755A

Reference37 articles.

1. Qualitative structure-metabolism relationships in the hydrolysis of carbamates

2. Organic Carbamates in Drug Design and Medicinal Chemistry

3. Metabolic Pathways of Agrochemicals: Insecticides and fungicides , ed. T. Roberts , D. Hutson , P. W. Lee , P. H. Nicholls and J. R. Plimmer , Royal Society of Chemistry , 1998

4. Combinatorial chemistry — applications of light-directed chemical synthesis

5. M. M. Mehndiratta , S.Pandey and T.Kuntzer , Cochrane db. Syst. Rev. , 2014, CD006986

Cited by 19 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Carbonic anhydrases;Metalloenzymes;2024

2. A simple yet multifaceted 90 years old, evergreen enzyme: Carbonic anhydrase, its inhibition and activation;Bioorganic & Medicinal Chemistry Letters;2023-09

3. Investigation of the effects of some pesticides on carbonic anhydrase isoenzymes;Journal of Molecular Recognition;2023-08-08

4. 6-Substituted Triazolyl Benzoxaboroles as Selective Carbonic Anhydrase Inhibitors: In Silico Design, Synthesis, and X-ray Crystallography;Journal of Medicinal Chemistry;2023-06-07

5. A Combined in Silico and Structural Study Opens New Perspectives on Aliphatic Sulfonamides, a Still Poorly Investigated Class of CA Inhibitors;Biology;2023-02-10