Development of an automated kinetic profiling system with online HPLC for reaction optimization-Reference-Cited by-同舟云学术

Development of an automated kinetic profiling system with online HPLC for reaction optimization

Published:2019 Issue:9 Volume:4 Page:1555-1558
ISSN:2058-9883
Container-title:Reaction Chemistry & Engineering
language:en
Short-container-title:React. Chem. Eng.

Author:

Christensen Melodie¹²³⁴⁵^ORCID,Adedeji Folarin¹²³⁴,Grosser Shane¹²³⁴,Zawatzky Kerstin⁶²³⁴,Ji Yining¹²³⁴^ORCID,Liu Jinchu⁶²³⁴,Jurica Jon A.¹²³⁴^ORCID,Naber John R.¹²³⁴^ORCID,Hein Jason E.⁵⁷⁸⁹^ORCID

Affiliation:

1. Process Research and Development

2. Merck & Co., Inc.

3. Rahway

4. USA

5. Department of Chemistry

6. Analytical Research and Development

7. The University of British Columbia

8. Vancouver

9. Canada

Abstract

Application of an automated profiling system with online HPLC uncovers an induction period in a cross-coupling and facilitates catalyst optimization.

Funder

University of British Columbia

Canada Foundation for Innovation

Merck

Publisher

Royal Society of Chemistry (RSC)

Subject

Fluid Flow and Transfer Processes,Process Chemistry and Technology,Chemical Engineering (miscellaneous),Chemistry (miscellaneous),Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2019/RE/C9RE00086K

Reference26 articles.

1. Analysis of Past and Present Synthetic Methodologies on Medicinal Chemistry: Where Have All the New Reactions Gone?

2. Design and Synthesis of Novel, Selective GPR40 AgoPAMs

3. A New Palladium Precatalyst Allows for the Fast Suzuki−Miyaura Coupling Reactions of Unstable Polyfluorophenyl and 2-Heteroaryl Boronic Acids

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