Synthesis and antimalarial activity of novel bicyclic and tricyclic aza-peroxides

Author:

Yadav Lalit12345,Tiwari Mohit K.12345,Kumar Shyamlal Bharti Rajesh12345,Mathur Manas6785,Swami Ajit K.6785,Puri Sunil K.910115,Naikade Niraj K.121011513,Chaudhary Sandeep12345

Affiliation:

1. Department of Chemistry

2. Malaviya National Institute of Technology

3. Jawaharlal Nehru Marg

4. Jaipur-302017

5. India

6. Department of Advance Molecular Microbiology

7. Seminal Applied Sciences Pvt. Ltd

8. Jaipur-302015

9. Division of Parasitology

10. CSIR-Central Drug Research Institute

11. Lucknow-226031

12. Division of Medicinal and Process Chemistry

13. Sandoz India Pvt. Ltd

Abstract

Bicyclic and tricyclic aza-peroxides were synthesized and assessed for theirin vitroandin vivoantimalarial activities againstPlasmodium falciparum(3D7 strain) andPlasmodium yoelii nigeriensisin Swiss mice by an oral route, respectively.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

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