Direct synthesis of fluorene-based spirolactones through a BF<sub>3</sub>-promoted spiroannulation of α-keto acids and <i>o</i>-alkynylbiaryls-Reference-Cited by-同舟云学术

Direct synthesis of fluorene-based spirolactones through a BF₃-promoted spiroannulation of α-keto acids and o-alkynylbiaryls

Published:2023 Issue:2 Volume:10 Page:363-368
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Song Qingting¹,Zhang Zhen¹,Xie Xiaoyu¹,Ding Guang-Zhu¹^ORCID,Li Pinhua¹^ORCID,Wang Lei¹²³^ORCID,Miao Tao¹^ORCID

Affiliation:

1. Key Laboratory of Green and Precise Synthetic Chemistry and Application, Ministry of Education, Department of Chemistry, Huaibei Normal University, Huaibei, Anhui 235000, P. R. China

2. Advanced Research Institute and Department of Chemistry, Taizhou University, Taizhou, Zhejiang 318000, P. R. China

3. State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, P R China

Abstract

A novel and practical approach to fluorene-based spirolactones has been described via BF3-promoted spiroannulation of α-keto acids and o-alkynyl biaryls. This metal-free cascade reaction provides a wide range of products in good to excellent yields.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Anhui Province

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/QO/D2QO01523D

Reference44 articles.

1. Two novel polycyclic spiro lignans from Gymnotheca involucrata

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