Discovering the role of N-heterocyclic carbene as hydrogen borrowing organocatalyst: metal-free, direct <i>N</i>-alkylation of amines with benzyl alcohols-Reference-Cited by-同舟云学术

Discovering the role of N-heterocyclic carbene as hydrogen borrowing organocatalyst: metal-free, direct N-alkylation of amines with benzyl alcohols

Published:2023 Issue:3 Volume:10 Page:730-744
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Sharma Richa¹,Rahaman T A Abdul²,Sen Janmejaya²,Mashevskaya Irina V.³,Chaudhary Sandeep¹²^ORCID

Affiliation:

1. Laboratory of Organic and Medicinal Chemistry (OMC lab), Department of Chemistry, Malaviya National Institute of Technology, Jawaharlal Nehru Marg, Jaipur-302017, India

2. Laboratory of Bioactive Heterocycles and Catalysis (BHC lab), Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research-Raebareli (Transit Campus), Bijnor–Sisendi Road, Near CRPF Base Camp, Sarojini Nagar, Lucknow-226002, India

3. Department of Organic Chemistry, Faculty of Chemistry, Perm State University, Bukireva Street, Perm 614990, Russian Federation

Abstract

A highly sustainable, bench-stable, inexpensive, non-toxic and commercially available N-heterocyclic carbene based hydrogen borrowing organocatalyst for the direct N-alkylation of amines with alcohols is reported.

Funder

Ministry of Education and Science of the Russian Federation

Malaviya National Institute of Technology, Jaipur

Department of Pharmaceuticals, Ministry of Chemicals and Fertilizers, India

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/QO/D2QO01522F

Reference63 articles.

1. Large-Scale Applications of Transition Metal-Catalyzed Couplings for the Synthesis of Pharmaceuticals