A one-pot multicomponent facile synthesis of dihydropyrimidin-2(1H)-thione derivatives using triphenylgermane as a catalyst and its binding pattern validation-Reference-Cited by-同舟云学术

A one-pot multicomponent facile synthesis of dihydropyrimidin-2(1H)-thione derivatives using triphenylgermane as a catalyst and its binding pattern validation

Published:2016 Issue:83 Volume:6 Page:79651-79661
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Andleeb Sohaila¹²³⁴,Imtiaz-ud-Din Imtiaz-ud-Din¹²³⁴,Rauf Muhammad Khawar¹²³⁴,Azam Syed Sikander⁵⁶²³⁴,Badshah Amin¹²³⁴,Sadaf Haseeba¹²³⁴,Raheel Ahmed¹²³⁴,Tahir Muhammad Nawaz⁷⁸⁹⁴,Raza Saad⁵⁶²³⁴

Affiliation:

1. Department of Chemistry

2. Quaid-i-Azam University

3. Islamabad-45320

4. Pakistan

5. Computational Biology Lab

6. National Center for Bioinformatics

7. Department of Physics

8. University of Sargodha

9. Sargodha

Abstract

A series of substituted dihydropyrimidin-2(1H)-thione derivatives (1–8) have been synthesized and docked against enzymes human topoisomerase II alpha (4FM9) and Helicobacter pylori urease (1E9Y) for binding mode validation.

Funder

Higher Education Commission, Pakistan

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/RA/C6RA19162B

Reference50 articles.

1. Silica sulfuric acid: an efficient and reusable catalyst for the one-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones

2. Synthesis and biological evaluation of novel pyrimidine-2(1H)-ones/thiones as potent anti-inflammatory and anticancer agents

3. Biologically active dihydropyrimidones of the Biginelli-type — a literature survey