A novel cyclic dinuclear gold(<scp>i</scp>) complex induces anticancer activity <i>via</i> an oxidative stress-mediated intrinsic apoptotic pathway in MDA-MB-231 cancer cells-Reference-Cited by-同舟云学术

A novel cyclic dinuclear gold(i) complex induces anticancer activity via an oxidative stress-mediated intrinsic apoptotic pathway in MDA-MB-231 cancer cells

Published:2022 Issue:7 Volume:51 Page:2760-2769
ISSN:1477-9226
Container-title:Dalton Transactions
language:en
Short-container-title:Dalton Trans.

Author:

Abogosh Ahmed K.¹,Alghanem Meshal K.¹,Ahmad Saeed²,Al-Asmari Abdullah¹,As Sobeai Homood M.¹,Sulaiman Adam A. A.³^ORCID,Fettouhi Mohammed³⁴,Popoola Saheed A.⁵,Alhoshani Ali¹^ORCID,Isab Anvarhusein A.³⁶^ORCID

Affiliation:

1. Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia

2. Department of Chemistry, College of Sciences and Humanities, Prince Sattam bin Abdulaziz University, Al-Kharj 11942, Saudi Arabia

3. Department of Chemistry, King Fahd University of Petroleum and Minerals, Dhahran 31261, Saudi Arabia

4. Center for Refining and Advanced Chemicals, King Fahd University of Petroleum and Minerals, Dhahran 31261, Saudi Arabia

5. Department of Chemistry, Faculty of Science, Islamic University of Madinah, Saudi Arabia

6. Interdisciplinary Research Center for Advanced Materials, King Fahd University of Petroleum and Minerals, Dhahran 31261, Saudi Arabia

Abstract

The complex was found to display cytotoxic effect via oxidative stress-mediated intrinsic apoptotic pathway in MDA-MB-231 cancer cells, as indicated by Annexin V-FITC/Propidium iodide double staining, ROS production, mitochondrial membrane potential and migration assays.

Funder

King Fahd University of Petroleum and Minerals

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/DT/D1DT03546K

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