Novel chelators based on adamantane-derived semicarbazones and hydrazones that target multiple hallmarks of Alzheimer's disease-Reference-Cited by-同舟云学术

Novel chelators based on adamantane-derived semicarbazones and hydrazones that target multiple hallmarks of Alzheimer's disease

Published:2018 Issue:21 Volume:47 Page:7190-7205
ISSN:1477-9226
Container-title:Dalton Transactions
language:en
Short-container-title:Dalton Trans.

Author:

Palanimuthu Duraippandi¹²³⁴⁵,Wu Zhixuan¹²³⁴⁵,Jansson Patric J.¹²³⁴⁵,Braidy Nady⁶⁷⁸⁴⁹^ORCID,Bernhardt Paul V.¹⁰¹¹¹²⁹^ORCID,Richardson Des R.¹²³⁴⁵,Kalinowski Danuta S.¹²³⁴⁵^ORCID

Affiliation:

1. Molecular Pharmacology and Pathology Program

2. Department of Pathology and Bosch Institute

3. The University of Sydney

4. Sydney

5. New South Wales

6. Centre for Healthy Brain Ageing

7. School of Psychiatry

8. University of New South Wales

9. Australia

10. School of Chemistry and Molecular Biosciences

11. University of Queensland

12. Brisbane

Abstract

Novel adamantane-derived semicarbazones and hydrazones show multi-functional activity as potential therapeutics for Alzheimer's disease.

Funder

National Health and Medical Research Council

Australian Research Council

Sydney Medical School

Judith Jane Mason and Harold Stannett Williams Memorial Foundation

Cancer Institute NSW

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/DT/C8DT01099D

Reference83 articles.

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4. Alzheimer's disease: Aβ, tau and synaptic dysfunction

5. The relationship between iron dyshomeostasis and amyloidogenesis in Alzheimer's disease: Two sides of the same coin

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