Author:
S. Kostić Marijana,M. Leovac Vukadin
Abstract
In light of the diverse chemical properties inherent in adamantane and its derivatives, this section shows an overview on adamantane-derived Schiff bases. Adamantane compounds, known for their diverse therapeutic applications, play a crucial role in drug discovery due to their hydrophobic nature, enabling modifications across different drug classes. The rigid cage structure of adamantane shields adjacent functional groups from metabolic cleavage, thereby augmenting drug stability and distribution in blood plasma. These derivatives and their complexes have exhibited the capability to disrupt various enzymes, showcasing a wide array of therapeutic activities, including anti-inflammatory, antiviral, antibacterial, antimicrobial, anticancer, anti-Parkinson, and antidiabetic effects. Highlighting the distinctive chemical attributes of the adamantyl scaffold, the significance of synthesizing and characterizing novel adamantane-derived compounds is underscored. The overview and comparative structural analysis of Schiff bases with adamantane moiety and their complex compounds contribute valuable insights to the realms of chemical synthesis, materials science, and medicinal chemistry.