Asperosin A, a [4 + 2] Diels–Alder cycloaddition polyketide dimer from <i>Aspergillus rugulosa</i> with immunosuppressive activity-Reference-Cited by-同舟云学术

Asperosin A, a [4 + 2] Diels–Alder cycloaddition polyketide dimer from Aspergillus rugulosa with immunosuppressive activity

Published:2022 Issue:9 Volume:9 Page:2477-2485
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Qiao Yuben¹^ORCID,Tan Xiaosheng²,Xu Qianqian¹,Zhang Zijun¹,Xu Qiaoxin¹,Tao Li³,Liu Junjun¹^ORCID,Zhu Hucheng¹,Chen Chunmei¹,Ye Ying¹,Lu Yuanyuan⁴,Chen Gang²,Qi Changxing¹,Zhang Yonghui¹^ORCID

Affiliation:

1. Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People's Republic of China

2. Key Laboratory of Organ Transplantation, Ministry of Education; NHC Key Laboratory of Organ Transplantation; Key Laboratory of Organ Transplantation, Chinese Academy of Medical Sciences, Wuhan, China

3. Ezhou Central Hospital, Ezhou 436000, People's Republic of China

4. Maternal and Child Health Hospital of Hubei Province, Tongji Medical College, Huazhong University of Science and Technology, People's Republic of China

Abstract

A novel homologous polyketide dimer, asperosin A (1), constructed with a unique hetero-bicycle 6/5 core skeleton featuring four continuous quaternary carbons, was isolated from a solid culture of the fungus Aspergillus rugulosa.

Funder

Ministry of Education of the People's Republic of China

National Science and Technology Planning Project

Innovative Research Group Project of the National Natural Science Foundation of China

Henan University of Science and Technology

China Postdoctoral Science Foundation

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

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