Rapid and efficient synthesis of a novel cholinergic muscarinic M1 receptor positive allosteric modulator using flash chemistry-Reference-Cited by-同舟云学术

Rapid and efficient synthesis of a novel cholinergic muscarinic M1 receptor positive allosteric modulator using flash chemistry

Published:2019 Issue:35 Volume:17 Page:8166-8174
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Miura Shotaro¹²³⁴⁵,Fukuda Koichiro¹²³⁴⁵,Masada Shinichi¹²³⁴⁵,Usutani Hirotsugu⁶⁷³⁴⁵^ORCID,Kanematsu Makoto⁶⁷³⁴⁵,Cork David G.⁶⁷³⁴⁵,Kawamoto Tetsuji¹²³⁴⁵^ORCID

Affiliation:

1. Neuroscience Drug Discovery Unit

2. Research

3. Takeda Pharmaceutical Company Ltd

4. Fujisawa

5. Japan

6. Process Chemistry

7. Pharmaceutical Sciences

Abstract

Continuous flash synthesis of a 2-bromobenzaldehyde derivative from the corresponding 1-bromo-2-iodobenzene derivative is described for rapid and efficient synthesis of a novel cholinergic muscarinic M₁ receptor positive allosteric modulator.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/OB/C9OB01718F

Reference68 articles.

1. Opportunities and challenges in the discovery of allosteric modulators of GPCRs for treating CNS disorders

2. Allosteric modulation of the M1 muscarinic acetylcholine receptor: improving cognition and a potential treatment for schizophrenia and Alzheimer's disease

3. The antipsychotic potential of muscarinic allosteric modulation

4. Muscarinic acetylcholine receptors as CNS drug targets

5. M1 Receptors Play a Central Role in Modulating AD-like Pathology in Transgenic Mice

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