Reinvestigation of diphenylmethylpiperazine analogues of pyrazine as new class of <i>Plasmodial</i> cysteine protease inhibitors for the treatment of malaria-Reference-Cited by-同舟云学术

Reinvestigation of diphenylmethylpiperazine analogues of pyrazine as new class of Plasmodial cysteine protease inhibitors for the treatment of malaria

Published:2024 Issue:3 Volume:15 Page:1022-1037
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Madhav Hari¹^ORCID,Reddy G. Srinivas²³^ORCID,Rizvi Zeba²³,Jameel Ehtesham¹,Patel Tarosh S.⁴^ORCID,Rahman Abdur⁵,Yadav Vikas⁶,Fatima Sadaf¹,Heyat Fatima¹,Pal Kavita¹,Minju-OP Amisha²,Subbarao Naidu⁶^ORCID,Bhattacharjee Souvik⁵,Dixit Bharat C.²,Sijwali Puran Singh²³,Hoda Nasimul¹^ORCID

Affiliation:

1. Drug Design and Synthesis Laboratory, Department of Chemistry, Jamia Millia Islamia (A Central University), New Delhi-110025, India

2. CSIR-Centre for Cellular and Molecular Biology, Hyderabad-500007, TS, India

3. Academy of Scientific and Innovative Research (AcSIR), Ghaziabad-201002, UP, India

4. Chemistry Department, V. P. & R. P. T. P Science College, Affiliated to Sardar Patel University, Vallabh Vidyanagar-388120, Gujarat, India

5. Special Centre for Molecular Medicine, Jawaharlal Nehru University, New Delhi-110067, India

6. School of Computational and Integrative Sciences, Jawaharlal Nehru University, New Delhi-110067, India

Abstract

The present study unveils a thorough reevaluation of diphenylmethylpiperazine and pyrazine-derived molecular hybrids, introducing them as a new class of antimalarials.

Funder

Indian Council of Medical Research

Council of Scientific and Industrial Research, India

Department of Biotechnology, Ministry of Science and Technology, India

Ministry of Education, India

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/MD/D3MD00490B

Reference62 articles.

1. Design, synthesis, and characterization of novel aminoalcohol quinolines with strong in vitro antimalarial activity

2. Identification, in-vitro anti-plasmodial assessment and docking studies of series of tetrahydrobenzothieno[2,3-d]pyrimidine-acetamide molecular hybrids as potential antimalarial agents

3. Design, Synthesis, Molecular Docking, Molecular Dynamics and In Vivo Antimalarial Activity of New Dipeptide‐Sulfonamides

4. Design and synthesis of new substituted spirooxindoles as potential inhibitors of the MDM2–p53 interaction

5. Design and synthesis of new 1,6-dihydropyrimidin-2-thio derivatives targeting VEGFR-2: Molecular docking and antiproliferative evaluation