Design and synthesis of new 1,6-dihydropyrimidin-2-thio derivatives targeting VEGFR-2: Molecular docking and antiproliferative evaluation-Reference-Cited by-同舟云学术

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Design and synthesis of new 1,6-dihydropyrimidin-2-thio derivatives targeting VEGFR-2: Molecular docking and antiproliferative evaluation

Published:2020-09 Issue: Volume:102 Page:104090
ISSN:0045-2068
Container-title:Bioorganic Chemistry
language:en
Short-container-title:Bioorganic Chemistry

Author:

Marzouk Adel A.,Abdel-Aziz Salah A.,Abdelrahman Kamal S.,Wanas Amira S.,Gouda Ahmed M.,Youssif Bahaa G.M.,Abdel-Aziz Mohamed

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Molecular Biology,Biochemistry

Reference40 articles.

1. Synthesis and antitumor activity of ureas containing pyrimidinyl group;Jin;Eur. J. Med. Chem.,2011

2. Synthesis of 3,4-Dihydropyrimidin-2(1H)-Ones;Biginelli;Chim. Ital.,1893

3. Synthesis and bioactivity evaluation of new 6-aryl-5-cyano thiouracils as potential antimicrobial and anticancer agents;Taher;MOLEFW.,2012

4. Select pyrimidinones inhibit the propagation of the malarial parasite, Plasmodium falciparum;Chiang;Bioorg. Med. Chem.,2009

5. Characterization of 2, 4-Diamino-6-oxo-1, 6-dihydropyrimidin-5-yl Ureido Based Inhibitors of Trypanosoma brucei FolD and Testing for Antiparasitic Activity;Eadsforth;J. Med. Chem.,2015

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1. Design and synthesis new indole-based aromatase/iNOS inhibitors with apoptotic antiproliferative activity;Frontiers in Chemistry;2024-09-06

2. Unveiling the impact: A decade review on dihydropyrimidinones (DHPMs) to combat breast cancer;Journal of Molecular Structure;2024-07

3. Novel NO-TZDs and trimethoxychalcone-based DHPMs: design, synthesis, and biological evaluation as potential VEGFR-2 inhibitors;Journal of Enzyme Inhibition and Medicinal Chemistry;2024-06-21

4. Recent advances and future directions on small molecule VEGFR inhibitors in oncological conditions;European Journal of Medicinal Chemistry;2024-06

5. Design, synthesis, and apoptotic antiproliferative action of new 1,2,3-triazole/1,2,4-oxadiazole hybrids as dual EGFR/VEGFR-2 inhibitors;Journal of Enzyme Inhibition and Medicinal Chemistry;2024-02-07

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