Dual role of BrCF<sub>2</sub>CO<sub>2</sub>Et: difluorocarbene-enabled access to α-trifluoromethyl ketones from sulfoxonium ylides-Reference-Cited by-同舟云学术

Dual role of BrCF₂CO₂Et: difluorocarbene-enabled access to α-trifluoromethyl ketones from sulfoxonium ylides

Published:2023 Issue:15 Volume:10 Page:3741-3745
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Wu Chun-Yan¹,Chen Xiang-Long¹,Wang Huai-Yu¹,Yang Dong-Sheng¹,Zhuang Shi-Yi¹,Zhou You¹,Yu Zhi-Cheng¹,Wu Yan-Dong¹,Geng Xiao²,Wu An-Xin¹^ORCID

Affiliation:

1. Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, P. R. China

2. Advanced Research Institute and School of Pharmaceutical Sciences, Taizhou University, Jiaojiang, Zhejiang, 318000, P. R. China

Abstract

A transition metal and external fluorine anion-free method has been developed for the efficient trifluoromethylation of sulfoxonium ylides with BrCF2CO2Et to afford α-trifluoromethyl ketones.

Funder

Fundamental Research Funds for the Central Universities

Higher Education Discipline Innovation Project

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/QO/D3QO00609C

Reference43 articles.

1. Transition-Metal (Cu, Pd, Ni)-Catalyzed Difluoroalkylation via Cross-Coupling with Difluoroalkyl Halides