N- and C-alkylation of seven-membered iminosugars generates potent glucocerebrosidase inhibitors and F508del-CFTR correctors-Reference-Cited by-同舟云学术

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N- and C-alkylation of seven-membered iminosugars generates potent glucocerebrosidase inhibitors and F508del-CFTR correctors

Published:2014 Issue:44 Volume:12 Page:8977-8996
ISSN:1477-0520
Container-title:Org. Biomol. Chem.
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Désiré J.¹²³⁴⁵,Mondon M.¹²³⁴⁵,Fontelle N.¹²³⁴⁵,Nakagawa S.⁶⁷⁸,Hirokami Y.⁶⁷⁸,Adachi I.⁶⁷⁸,Iwaki R.⁶⁷⁸,Fleet G. W. J.⁹¹⁰¹¹,Alonzi D. S.¹²¹³¹⁴¹⁵,Twigg G.¹²¹³¹⁴¹⁵,Butters T. D.¹²¹³¹⁴¹⁵,Bertrand J.¹⁶⁵¹⁷¹⁸,Cendret V.¹²³⁴⁵,Becq F.¹⁶⁵¹⁷¹⁸,Norez C.¹⁶⁵¹⁷¹⁸,Marrot J.¹⁹²⁰²¹,Kato A.⁶⁷⁸,Blériot Y.¹²³⁴⁵

Affiliation:

1. UMR-CNRS7285

2. IC2MP

3. Equipe “Synthèse Organique”

4. Groupe “Glycochimie”

5. Université de Poitiers

6. Department of Hospital Pharmacy

7. University of Toyama

8. Toyama 930-0194, Japan

9. Chemistry Research Laboratory

10. Oxford University

11. Oxford OX1 3TA, UK

12. Oxford Glycobiology Institute

13. Department of Biochemistry

14. University of Oxford

15. Oxford OX1 3QY, UK

16. Institut de Physiologie et Biologie Cellulaires

17. FRE 3511 CNRS

18. 86022 Poitiers cedex, France

19. Institut Lavoisier de Versailles

20. UMR CNRS 8180

21. 78035 Versailles cedex, France

Abstract

The synthesis and biological evaluation of a library of novel seven-membered iminosugars is reported.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2014/OB/C4OB00325J

Reference52 articles.

1. O. R. Martin and P.Compain , Iminosugars: From synthesis to therapeutic applications , Wiley-VCH , Weinheim , 2007

2. Therapeutic Applications of Iminosugars: Current Perspectives and Future Opportunities

3. Iminosugars past, present and future: medicines for tomorrow

4. Iminosugars as therapeutic agents: recent advances and promising trends

5. Glycosylation inhibitors in biology and medicine

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