Applications of covalent chemistry in targeted protein degradation-Reference-Cited by-同舟云学术

Applications of covalent chemistry in targeted protein degradation

Published:2022 Issue:22 Volume:51 Page:9243-9261
ISSN:0306-0012
Container-title:Chemical Society Reviews
language:en
Short-container-title:Chem. Soc. Rev.

Author:

Lu Dong¹,Yu Xin¹,Lin Hanfeng¹^ORCID,Cheng Ran¹,Monroy Erika Y.¹^ORCID,Qi Xiaoli¹,Wang Meng C.²³⁴,Wang Jin¹⁵^ORCID

Affiliation:

1. Department of Pharmacology and Chemical Biology, Baylor College of Medicine, Houston TX 77030, USA

2. Department of Molecular and Human Genetics, Baylor College of Medicine, Houston TX 77030, USA

3. Huffington Center on Aging, Baylor College of Medicine, Houston TX 77030, USA

4. Howard Hughes Medical Institute, Baylor College of Medicine, Houston TX 77030, USA

5. Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston TX 77030, USA

Abstract

This review summarizes the recent work of covalent chemistry in targeted protein degradation and describes the concept, pros and cons, development, and the outlook of covalent PROTACs.

Funder

Welch Foundation

National Cancer Institute

Cancer Prevention and Research Institute of Texas

National Institute of General Medical Sciences

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/CS/D2CS00362G

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