Enantioselective construction of substituted hydantoins <i>via</i> chiral phosphoric acid catalyzed annulation/Heyns rearrangement of aryl-substituted ureas with glyoxals-Reference-Cited by-同舟云学术

Enantioselective construction of substituted hydantoins via chiral phosphoric acid catalyzed annulation/Heyns rearrangement of aryl-substituted ureas with glyoxals

Published:2023 Issue:22 Volume:10 Page:5631-5636
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Wang Yong¹^ORCID,Li Jingyuan²,Li Yanyan¹,Pi Chao¹^ORCID,Wu Yangjie¹^ORCID,Cui Xiuling¹^ORCID

Affiliation:

1. Henan Key Laboratory of Chemical Biology and Organic Chemistry, Key Laboratory of Applied Chemistry of Henan Universities, Green Catalysis Center, and College of Chemistry, Zhengzhou University, 75 Daxue Road North, Zhengzhou, 450052, China

2. School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China

Abstract

The de novo organocatalyzed enantioselective construction of hydantoins from urea and glyoxal is presented. Chiral phosphoric acid catalyzed [3 + 2] heteroannulation/enantioselective Heyns rearrangement is proposed to be involved.

Funder

Ministry of Science and Technology of the People's Republic of China

Science and Technology Department of Henan Province

Zhengzhou University

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/QO/D3QO01194A

Reference29 articles.

1. Recent Advances in the Synthesis of Hydantoins: The State of the Art of a Valuable Scaffold