Two approaches for the synthesis of levo-praziquantel

Author:

Shou Haowen12345,He Zhaoting678,Peng Gang97108,Su Weike12345ORCID,Yu Jingbo12345ORCID

Affiliation:

1. National Engineering Research Center for Process Development of Active Pharmaceutical Ingredients

2. Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals

3. Zhejiang University of Technology

4. Hangzhou 310014

5. PR China

6. Beijing Fukangren Bio-pharm Tech Co.

7. Ltd

8. P. R. China

9. Huadong Medicine Co.

10. Hangzhou 310011

Abstract

Two pathways for the preparation of levo-praziquantel are herein reported, which involves mechanochemical (asymmetric) aza-Henry/acylation reaction, hydrogenation reaction, (chiral resolution) and solvent-free acylation-ring closing reaction.

Funder

Science and Technology Program of Zhejiang Province

Natural Science Foundation of Zhejiang Province

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Reference60 articles.

1. WHO , Schistosomiasis, Available from: https://www.who.int/news-room/fact-sheets/detail/schistosomiasis (accessed March 2020)

2. 21th WHO model list of essential medicines. Available at https://apps.who.int/iris/bitstream/handle/10665/325771/WHO-MVP-EMP-IAU-2019.06-eng.pdf?sequence=1&isAllowed=y

3. Praziquantel Treatment in Trematode and Cestode Infections: An Update

4. Praziquantel: A Review

5. Resolution of Praziquantel

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