α-C–H functionalization of glycine derivatives under mechanochemical accelerated aging en route the synthesis of 1,4-dihydropyridines and α-substituted glycine esters-Reference-Cited by-同舟云学术

α-C–H functionalization of glycine derivatives under mechanochemical accelerated aging en route the synthesis of 1,4-dihydropyridines and α-substituted glycine esters

Published:2023 Issue:7 Volume:25 Page:2853-2862
ISSN:1463-9262
Container-title:Green Chemistry
language:en
Short-container-title:Green Chem.

Author:

Xiang Keyu¹^ORCID,Ying Ping¹²,Ying Tao¹,Su Weike¹^ORCID,Yu Jingbo¹^ORCID

Affiliation:

1. National Engineering Research Center for Process Development of Active Pharmaceutical Ingredients, Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology. Hangzhou. 310014, P. R. China

2. College of Ecology, Lishui University, Lishui, 323000, P.R. China

Abstract

A novel accelerated aging cross dehydrogenative coupling of glycine esters/amides and various nucleophiles under metal-free and solvent-minimal conditions was developed, providing a sustainable strategy to the synthesis of 1,4-DHP and α-substituted glycine derivatives.

Funder

Natural Science Foundation of Zhejiang Province

Key Technologies Research and Development Program

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Pollution,Environmental Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/GC/D3GC00538K

Reference87 articles.

1. Mechanochemistry: opportunities for new and cleaner synthesis