Development of fluorogenic substrates for colorectal tumor-related neuropeptidases for activity-based diagnosis-Reference-Cited by-同舟云学术

Development of fluorogenic substrates for colorectal tumor-related neuropeptidases for activity-based diagnosis

Published:2023 Issue:17 Volume:14 Page:4495-4499
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Nagano Norimichi¹^ORCID,Ichihashi Yuki¹,Komatsu Toru¹,Matsuzaki Hiroyuki²,Hata Keisuke²,Watanabe Toshiaki²,Misawa Yoshihiro¹,Suzuki Misa¹,Sakamoto Shingo¹,Kagami Yu¹,Kashiro Ayumi³,Takeuchi Keiko³,Kanemitsu Yukihide⁴,Ochiai Hiroki⁴,Watanabe Rikiya⁵^ORCID,Honda Kazufumi³⁶,Urano Yasuteru¹⁷

Affiliation:

1. Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan

2. Department of Surgical Oncology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan

3. Institute for Advanced Medical Sciences, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-0033, Japan

4. National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan

5. Cluster for Pioneering Research, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan

6. Graduate School of Medicine, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8602, Japan

7. Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan

Abstract

We revealed higher neurolysin activity in the blood samples of patients with colorectal tumors, indicating that single-molecule neurolysin activity is a promising candidate for a blood biomarker for colorectal cancer diagnosis.

Funder

Japan Agency for Medical Research and Development

Precursory Research for Embryonic Science and Technology

Core Research for Evolutional Science and Technology

Japan Science and Technology Agency

Ministry of Education, Culture, Sports, Science and Technology

Naito Foundation

Mochida Memorial Foundation for Medical and Pharmaceutical Research

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry