Biosynthetic reconstitution of deoxysugar phosphoramidate metalloprotease inhibitors using an N–P-bond-forming kinase-Reference-Cited by-同舟云学术

Biosynthetic reconstitution of deoxysugar phosphoramidate metalloprotease inhibitors using an N–P-bond-forming kinase

Published:2019 Issue:16 Volume:10 Page:4486-4490
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Baulig Alexandra¹²³⁴⁵,Helmle Irina¹²³⁴⁵,Bader Marius¹²³⁴⁵,Wolf Felix¹²³⁴⁵,Kulik Andreas⁶⁷³⁴⁵^ORCID,Al-Dilaimi Arwa⁸⁹¹⁰⁵,Wibberg Daniel⁸⁹¹⁰⁵,Kalinowski Jörn⁸⁹¹⁰⁵^ORCID,Gross Harald¹²³⁴⁵^ORCID,Kaysser Leonard¹²³⁴⁵^ORCID

Affiliation:

1. Department of Pharmaceutical Biology

2. Pharmaceutical Institute

3. University of Tübingen

4. 72076 Tübingen

5. Germany

6. Interfaculty Institute for Microbiology and Infection Medicine Tübingen (IMIT)

7. Microbiology/Biotechnology

8. Center for Biotechnology (CeBiTec)

9. Bielefeld University

10. 33615 Bielefeld

Abstract

In the biosynthesis of phosphoramidon-like metalloprotease inhibitors three enzymes cooperate in the condensation of two amino acids and the subsequent attachment of a 6-deoxyhexose via a phosporamidate bridge.

Funder

Deutsche Forschungsgemeinschaft

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/SC/C9SC00641A

Reference35 articles.

1. Aryloxy Phosphoramidate Triesters: a Technology for Delivering Monophosphorylated Nucleosides and Sugars into Cells

2. Peptidomimetics, a synthetic tool of drug discovery

3. Crystallographic structural analysis of phosphoramidates as inhibitors and transition-state analogs of thermolysin