Synthesis and in vivo stability studies of [18F]-zwitterionic phosphonium aryltrifluoroborate/indomethacin conjugates-Reference-Cited by-同舟云学术

Synthesis and in vivo stability studies of [18F]-zwitterionic phosphonium aryltrifluoroborate/indomethacin conjugates

Published:2016 Issue:28 Volume:6 Page:23126-23133
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Chansaenpak Kantapat¹²³⁴,Wang Mengzhe⁵⁶⁷⁸⁴,Liu Shuanglong⁹⁵¹⁰¹¹⁴,Wu Zhanhong⁵⁶⁷⁸⁴,Yuan Hong⁵⁶⁷⁸⁴,Conti Peter S.⁹⁵¹⁰¹¹⁴,Li Zibo⁵⁶⁷⁸⁴,Gabbaï François P.¹²³⁴

Affiliation:

1. Department of Chemistry

2. Texas A&M University

3. College Station

4. USA

5. Department of Radiology

6. Biomedical Research Imaging Center

7. University of North Carolina

8. Chapel Hill 27599

9. Molecular Imaging Center

10. University of Southern California

11. Los Angeles 90033

Abstract

Conjugation of ortho-phosphonium phenyltrifluoroborates with indomethacin affords conjugates which have been radiolabeled by ¹⁸F–¹⁹F isotopic exchange in aqueous solutions and imaged by positron emission tomography in mice.

Funder

National Cancer Institute

Cancer Prevention and Research Institute of Texas

National Institute of Biomedical Imaging and Bioengineering

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/RA/C5RA26323A

Reference56 articles.

1. [18F]-Group 13 fluoride derivatives as radiotracers for positron emission tomography