Focus on PAINS: false friends in the quest for selective anti-protozoal lead structures from Nature?-Reference-Cited by-同舟云学术

Focus on PAINS: false friends in the quest for selective anti-protozoal lead structures from Nature?

Published:2016 Issue:2 Volume:7 Page:214-223
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Glaser J.¹²³⁴,Holzgrabe U.¹²³⁴

Affiliation:

1. Institute of Pharmacy and Food Chemistry

2. University of Wuerzburg

3. 97074 Wuerzburg

4. Germany

Abstract

Pan-assay interference compounds (PAINS) are molecules showing promising but deceptive activities in various biochemical screenings mainly due to unselective interactions with the target.

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/MD/C5MD00481K

Reference112 articles.

1. Antimalarial drug resistance in Africa: key lessons for the future

2. Drug resistance in leishmaniasis

3. Qinghaosu (Artemisinin): an Antimalarial Drug from China

4. Plant antitumor agents. VI. Isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia

5. Antileishmanial High-Throughput Drug Screening Reveals Drug Candidates with New Scaffolds

Cited by 35 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Master Molecules of Spices;Handbook of Spices in India: 75 Years of Research and Development;2023-10-27

2. Current and emerging approaches to noncompetitive AR inhibition;Medicinal Research Reviews;2023-04-16

3. Retrospective Review of Chromane Analogues as Anti-protozoal Leads: A Decade's Worth of Evolution;Current Topics in Medicinal Chemistry;2023-04

4. In silico toxicologic profile and in vivo trypanocidal activity of estafietin, a sesquiterpene lactone isolated from Stevia alpina Griseb.;Natural Product Research;2023-03-20

5. Identification of 1,4-Benzodiazepine-2,5-dione Derivatives as Potential Protein Synthesis Inhibitors with Highly Potent Anticancer Activity;Journal of Medicinal Chemistry;2022-10-19