Exploring structural requirements for the inhibition of Plasmodium falciparum calcium-dependent protein kinase-4 (PfCDPK-4) using multiple in silico approaches-Reference-Cited by-同舟云学术

Exploring structural requirements for the inhibition of Plasmodium falciparum calcium-dependent protein kinase-4 (PfCDPK-4) using multiple in silico approaches

Published:2016 Issue:57 Volume:6 Page:51957-51982
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Aher Rahul Balasaheb¹²³⁴⁵,Roy Kunal¹²³⁴⁵

Affiliation:

1. Drug Theoretics and Cheminformatics Laboratory

2. Department of Pharmaceutical Technology

3. Jadavpur University

4. Kolkata 700032

5. India

Abstract

Plasmodial protein kinases represent one of the most important thrust areas for antimalarial drug discovery.

Funder

University Grants Commission

Indian Council of Medical Research

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/RA/C6RA05692J

Reference31 articles.

1. World Health Organization , World Malaria Report 2012, World Health Organization, Geneva, 2012, available at: http://www.who.int/malaria/publications/world_malaria_report_2012/en, accessed 22 Feb. 2016

2. First report on exploring classification and regression based QSAR modelling ofPlasmodium falciparumglycogen synthase kinase (PfGSK-3) inhibitors

3. Development of potent and selective Plasmodium falciparum calcium-dependent protein kinase 4 (PfCDPK4) inhibitors that block the transmission of malaria to mosquitoes

4. Characteristics of the Plasmodium falciparum PK5 ATP-binding site: implications for the design of novel antimalarial agents

5. Selective inhibition of Pfmrk, a Plasmodium falciparum CDK, by antimalarial 1,3-diaryl-2-propenones

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