Abstract
Malaria control relies heavily on the small number of existing antimalarial drugs. However, recurring antimalarial drug resistance necessitates the continual generation of new antimalarial drugs with novel modes of action. In order to shift the focus from only controlling this disease towards elimination and eradication, next-generation antimalarial agents need to address the gaps in the malaria drug arsenal. This includes developing drugs for chemoprotection, treating severe malaria and blocking transmission. Plasmodial kinases are promising targets for next-generation antimalarial drug development as they mediate critical cellular processes and some are active across multiple stages of the parasite’s life cycle. This review gives an update on the progress made thus far with regards to plasmodial kinase small-molecule inhibitor development.
Subject
Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science
Reference185 articles.
1. World Malaria Report
https://www.who.int/malaria/publications/world_malaria_report/en/
2. The Potential Impact of Health Service Disruption on the Burden of Malaria: A Modelling Analysis for Countries in Sub-Saharan Africa
https://www.who.int/publications/i/item/the-potential-impact-of-health-service-disruptions-on-the-burden-of-malaria
3. Pausing the Fight Against Malaria to Combat the COVID-19 Pandemic in Africa: Is the Future of Malaria Bleak?
4. Status Report on Artemisinin Resistance and Artemisinin-Based Combination Therapy Efficacy
https://www.who.int/malaria/areas/drug_resistance/updates/en/
5. Molecular detection of drug resistant malaria in Southern Thailand
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