Thermal behavior and molecular mobility in the glassy state of three anti-hypertensive pharmaceutical ingredients
Author:
Affiliation:
1. CQFM – Centro de Química-Física Molecular and IN – Institute of Nanoscience and Nanotechnology
2. Instituto Superior Técnico
3. Universidade de Lisboa
4. 1049-001 Lisboa
5. Portugal
6. CQE – Centro de Química Estrutural
7. Complexo I
Abstract
Good agreement was found between the thermodynamic and kinetic fragilities of these APIs. DSC analysis of irbesartan showed the possibility of transformation A → B between the two monotropic polymorphic forms.
Funder
Fundação para a Ciência e a Tecnologia
Publisher
Royal Society of Chemistry (RSC)
Subject
General Chemical Engineering,General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2017/RA/C7RA00298J
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4. On the solubility advantage of a pharmaceutical’s glassy state over the crystal state, and of its crystal polymorphs
5. Influence of Molecular Mobility on the Physical Stability of Amorphous Pharmaceuticals in the Supercooled and Glassy States
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