Influence of Molecular Mobility on the Physical Stability of Amorphous Pharmaceuticals in the Supercooled and Glassy States
Author:
Affiliation:
1. Department of Pharmaceutics, University of Minnesota, 308 Harvard Street SE, Minneapolis, Minnesota 55455, United States
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Pharmaceutical Science,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/mp500229d
Reference48 articles.
1. Solid dispersions as strategy to improve oral bioavailability of poor water soluble drugs
2. Characteristics and Significance of the Amorphous State in Pharmaceutical Systems
3. Solubility Advantage of Amorphous Pharmaceuticals: II. Application of Quantitative Thermodynamic Relationships for Prediction of Solubility Enhancement in Structurally Diverse Insoluble Pharmaceuticals
4. Local Mobility in Amorphous Pharmaceuticals—Characterization and Implications on Stability
5. Role of Thermodynamic, Molecular, and Kinetic Factors in Crystallization from the Amorphous State
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