Minimalist linkers suitable for irreversible inhibitors in simultaneous proteome profiling, live-cell imaging and drug screening-Reference-Cited by-同舟云学术

Minimalist linkers suitable for irreversible inhibitors in simultaneous proteome profiling, live-cell imaging and drug screening

Published:2019 Issue:6 Volume:55 Page:834-837
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Guo Cuiping¹²³,Chang Yu¹²³,Wang Xin¹²³,Zhang Chengqian⁴⁵³,Hao Piliang⁴⁵³,Ding Ke¹²³,Li Zhengqiu¹²³^ORCID

Affiliation:

1. School of Pharmacy, Jinan University, Guangzhou City Key Laboratory of Precision Chemical Drug Development, International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development, Ministry of Education (MOE) of People's Republic of China

2. Guangzhou

3. China

4. School of Life Science and Technology, ShanghaiTech University

5. Shanghai 201210

Abstract

A series of minimalist linkers were developed and have been demonstrated to be suitable for irreversible inhibitors in simultaneous proteome profiling, live-cell imaging and drug screening, thus facilitating the discovery of first-in-class anticancer drugs.

Funder

National Natural Science Foundation of China

China Postdoctoral Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2019/CC/C8CC08685K

Reference24 articles.

1. Phenotypic screening in cancer drug discovery — past, present and future

2. Target identification and mechanism of action in chemical biology and drug discovery

3. Click chemistry enables preclinical evaluation of targeted epigenetic therapies

4. Imaging of anticancer drug action in single cells

5. Activity-Based Proteome Profiling of Potential Cellular Targets of Orlistat − An FDA-Approved Drug with Anti-Tumor Activities

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