Intramolecular N–Me and N–H aminoetherification for the synthesis of N-unprotected 3-amino-O-heterocycles-Reference-Cited by-同舟云学术

Intramolecular N–Me and N–H aminoetherification for the synthesis of N-unprotected 3-amino-O-heterocycles

Published:2021 Issue:3 Volume:19 Page:557-560
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Paudyal Mahesh P.¹²³⁴⁵,Wang Mingliang⁶⁷⁸⁹,Siitonen Juha H.¹⁰¹¹¹²⁵^ORCID,Hu Yimin¹³¹⁴¹⁵⁸⁹,Yousufuddin Muhammed¹⁶¹⁷¹⁸⁴⁵,Shen Hong C.¹³¹⁴¹⁵⁸⁹,Falck John R.¹²³⁴⁵^ORCID,Kürti László¹⁰¹¹¹²⁵^ORCID

Affiliation:

1. Division of Chemistry

2. Departments of Biochemistry and Pharmacology

3. University of Texas Southwestern Medical Center

4. Dallas

5. USA

6. Department of Natural Products Chemistry

7. Fudan University

8. Shanghai 201203

9. P. R. China

10. Department of Chemistry

11. Rice University

12. Houston

13. Roche Pharma Research & Early Development

14. Roche Innovation Center Shanghai

15. Roche R&D Center (China) Ltd

16. Life and Health Sciences Department

17. The University of North Texas at Dallas

18. 7400 University Hills Boulevard

Abstract

A mild Rh-catalyzed method for synthesis of cyclic unprotected N–Me and N–H 2,3-aminoethers using an olefin aziridination–aziridine ring-opening domino reaction has been developed.

Funder

Rice University

Welch Foundation

Division of Chemistry

Osk. Huttusen säätiö

National Institute of General Medical Sciences

Amgen

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

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