Chemical synthesis of human trefoil factor 1 (TFF1) and its homodimer provides novel insights into their mechanisms of action-Reference-Cited by-同舟云学术

Chemical synthesis of human trefoil factor 1 (TFF1) and its homodimer provides novel insights into their mechanisms of action

Published:2020 Issue:47 Volume:56 Page:6420-6423
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Braga Emidio Nayara¹²³⁴^ORCID,Baik Hayeon⁵⁶⁷⁸⁹,Lee David¹²³⁴,Stürmer René¹⁰¹¹¹²¹³,Heuer Jörn¹⁰¹¹¹²¹³,Elliott Alysha G.¹²³⁴^ORCID,Blaskovich Mark A. T.¹²³⁴^ORCID,Haupenthal Katharina¹⁰¹¹¹²¹³,Tegtmeyer Nicole¹⁴¹⁵¹⁶¹⁷¹³,Hoffmann Werner¹⁰¹¹¹²¹³,Schroeder Christina I.¹²³⁴¹⁸^ORCID,Muttenthaler Markus¹²³⁴⁵^ORCID

Affiliation:

1. Institute for Molecular Bioscience

2. The University of Queensland

3. St Lucia, Brisbane

4. Australia

5. Institute of Biological Chemistry

6. Faculty of Chemistry

7. University of Vienna

8. Vienna

9. Austria

10. Institute of Molecular Biology and Medicinal Chemistry

11. Otto-von-Guericke-University Magdeburg

12. 39120 Magdeburg

13. Germany

14. Division of Microbiology

15. Department of Biology

16. Friedrich-Alexander-University

17. 91058 Erlangen

18. National Cancer Institute

Abstract

Chemical synthesis of gut peptide TFF1 and its homodimer was achieved by a two-fragment ligation strategy followed by oxidative folding.

Funder

Wellcome Trust

Horizon 2020 Framework Programme

Australian Research Council

University of Queensland

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2020/CC/D0CC02321C

Reference45 articles.

1. Trefoil Factor Family: Unresolved Questions and Clinical Perspectives

2. Trefoil factors: initiators of mucosal healing

3. The pS2/TFF1 trefoil factor, from basic research to clinical applications

4. Molecular Alterations in the Stomach of Tff1-Deficient Mice: Early Steps in Antral Carcinogenesis

5. The Tumor Suppressor TFF1 Occurs in Different Forms and Interacts with Multiple Partners in the Human Gastric Mucus Barrier: Indications for Diverse Protective Functions

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