Metal-free 1,3-dipolar cyclization of azides with HFO-1233zd(<i>E</i>) in the presence of amines: one-step regioselective synthesis of 1-<i>N</i>-substituted 1,2,3-triazole-4-carboxamide derivatives-Reference-Cited by-同舟云学术

Metal-free 1,3-dipolar cyclization of azides with HFO-1233zd(E) in the presence of amines: one-step regioselective synthesis of 1-N-substituted 1,2,3-triazole-4-carboxamide derivatives

Published:2023 Issue:12 Volume:10 Page:3016-3020
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Wang Jing¹²,Yu Qian¹²,Wang Zheng¹²,Zhang Zheteng²,Zeng Linghui²,Zhang Chong²,Zhu Huajian¹²^ORCID,Shao Jiaan¹²^ORCID,Zhang Jiankang¹²^ORCID

Affiliation:

1. College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, PR China

2. Key Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province, School of Medicine, Hangzhou City University, Hangzhou, 310015, PR China

Abstract

A simple and metal-free strategy for the regioselective synthesis of 1-N-substituted 1,2,3-triazole-4-carboxamide derivatives was developed by employing azides, HFO-1233zd(E) and amines in an aqueous reaction medium.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/QO/D3QO00333G

Reference31 articles.

1. Synthesis of 1-(2-Aminovinyl)indoles and 1,3′-Biindoles by Reaction of 2,2-Diaryl-Substituted 2H-Azirines with α-Imino Rh(II) Carbenoids

2. 1,2,3-Triazole-containing hybrids as leads in medicinal chemistry: A recent overview

3. Efficiency and Fidelity in a Click-Chemistry Route to Triazole Dendrimers by the Copper(I)-Catalyzed Ligation of Azides and Alkynes

4. Synthesis and CB1 cannabinoid receptor affinity of 4-alkoxycarbonyl-1,5-diaryl-1,2,3-triazoles

5. Synthesis and Evaluation of New Hsp90 Inhibitors Based on a 1,4,5-Trisubstituted 1,2,3-Triazole Scaffold

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